We've seen a lot of NES mods, but this NES with Mac Mini guts is a first for us. From the article: "Inside you will find simply, a Mac Mini, a DVD writer, and the IDE to USB 2.0 circuitry... The power button does just what it says, as well as putting the Mac into sleep mode."
The dude even got the reset button to eject the DVD tray, not to mention motorized opening of the cartridge lid. Follow the link to see more photos along with modification details.
The Nintendo PC casemod; NES HTPC
NES alarm clock; hit Reset to sleep in