It's too bad I didn't know about Curio from Zengobi when I was writing the Get Organized post, as it seems to take quite an interesting approach to collecting, jotting down and organizing information. Billed as an app that "promotes visual thinking gathering and shaping your ideas", Curio definitely seems to be more like a sketchpad than many other similar applications. You can literally place anything anywhere on the page, and includes tools for sketching and drawing - just look at the screenshot which includes an image, lists, an embedded video and some chicken scratch.
Curio doesn't stop there though. It also includes a project center, presentation mode, a powerful search companion, tags, LinkBack support, project archiving, web/.Mac publishing and iPhoto exporting. I haven't played with this app yet, but I'm downloading a demo as I type up this post to play with later. Some features, however, are only included in certain editions, so check out Zengobi's feature comparison chart to determine which edition is right for you. A demo is available, while full licenses start at $39.