The author, an admitted non-gamer, argues that video games are inherently meaningless and simply serve as an escape from the harsh reality of the real world. Further, he says that people who eschew "real" experiences to sit in front of a monitor for hours on end turn into "a bunch of guys who's only recourse when 'times get tough' is to dive into a world ruled by megabytes."
Obviously, games are no replacement for actually living life, but everyone needs an occasional escape from the day-to-day grind. Just because playing a game of Madden is more sedentary than playing a real game of football doesn't mean it's inherently worse, as long as the correct balance is kept. Everything in moderation, as they say.