The full rules can be found on the contest main page. Entrants need not make the game themselves but are expected to have a fleshed-out idea that meets the listed criteria. The winner will receive $5,000 and the chance to help mtvU create the final game. Those with a few brilliant ideas and the determination to make a design need to complete the application form by March 16.
Last year's contest, where entrants were asked to make a game about the crisis in Sudan, spawned the oft-discussed title Darfur is Dying. You can play the game here.
[Via Game Politics]