Puchi Puchi Virus is a puzzle game from Keys Factory, a company that generally sticks to game accessories. It's published in Japan by JALECO, who published things like the NES port of Maniac Mansion and Irritating Stick for the Playstation-- we didn't even know they still existed.
The gameplay looks like a slightly novel puzzle game based around capturing same-colored items inside a wide beam. But the art is stunning. The DS can do some excellent 2D in the right hands, and Puchi Puchi Virus has some of the best we've seen recently. The characters are vibrant and presented in an anime style, while the backgrounds are more in the whimsical, highly-stylized form of modern Western animation like Dexter's Laboratory.