Considering the graphical nature of the web, I'm surprised more features and plug-ins haven't appeared to solve the problem of downloading images from sites as well as iPlace does. Operating as a SIMBL plug-in for Safari (including the 3.0 beta), iPlace allows you to specify multiple locations on your Mac for downloading images, but that's not all. It then gives you a contextual menu item when right-clicking an image or a web page that will allow you to instantly download any image to one of your specified locations, or - and here's the kicker - bring up an image downloading window that shows you each image on the page, along with your download locations provided as drag and drop wells in a sidebar on the left. Opening this window on I CAN HAS CHEEZBURGER, for example, brings up the long list of images you see above, all ripe for efficiently dragging and dropping wherever I want.
In a word: iPlace is awesome. There are of course enhancements I would like to see, such as the ability to scale these images up and down to make it easier to view more from the page at once, but for a spankin' new product straight out the gate, this is a really handy plug-in.
iPlace is provided as donationware from Tekuris.