Synium's Screenium, which is currently in beta preview, is a new arrival in an already teeming category of software. It has standard features like fullscreen, fixed area and mouse-follow capture, hotkey integration and adjustable quality/frame rate with capture presets. It also boasts a single window capture mode and frame rates up to 60fps. I don't know why you'd need to capture a screen at 60fps, but it can't hurt to know it's available.
In my testing, Screenium performed exceptionally well in the area of small filesize, high quality captures and its default presets were simple and useful. It also gets high marks for ease of use. And it didn't max out my CPU and turn my fans into Harrier jets after 2 minutes, which is kind of nice when you're recording microphone audio. It's got some distance to cover before the official release in February, but Screenium is looking like a strong contender.