Keep in mind, this is not the Wii version
Take note, webheads: a new Spidey game is being made for the Wii (along with those other systems nobody cares about). It's called Spider-Man: Web of Shadows and will once again feature the tried-and-true sandbox mechanic of a fully-explorable New York City. Other than that, we know that the game is being worked on by Treyarch and Shaba Games and will feature some kind of system that allows for customizable superpowers. Also, players will have some control in determining whether they want to be the boyscout do-gooder or a more selfish anti-hero type.
Perhaps even cooler than the news of there being a new game is word that Activision will be holding auditions for folks to do the voiceover work in the game at their booth at the upcoming New York Comic-Con. The winner will be determined by open voting, which will go down at the game's official website here.