The underlying message of Brown's presentation, titled "10 Things Nobody Tells You About Digital Distribution and Self-publishing That You Must Understand to Succeed," seemed to be one of caution, as summarized by Gamasutra. Brown dispelled much of the get-rich-quick myth of independent, digital development -- and publishing. Sure, one in a billion basement programmers might strike gold, but to enjoy lasting success, as Team17 has for nearly two decades, expect to spend money to make money and employ a staff with a "wide variety of skills" (a team of 30 or so is currently working on Alien Breed, for example). Brown warned, "if you don't know something, get someone who does, because you will not be able to wing it."
Update: It's coming to PC too.
Source - Alien Breed trilogy cost $2.5 million to make
Source - Alien Breed trilogy: PS3 version coming later
Source - Develop 2009: Team17's Brown Talks Challenges Of Self-Publishing Online