Look, if you don't have a mouse designed exclusively to play your favorite types of games, you're doing it wrong. At least, that's what Razer wants you to think. The company recently released it's Naga Hex mouse, which was created especially for MOBAs and action-RPGs, with six side-mounted buttons just for activating in-game skills.
If your mouse just doesn't have enough buttons – or perhaps has too many – the Hex just might help you out, assuming you're willing to shell out 80 bucks, of course. Check out Joystiq's overview of the Naga Hex above.