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I bet you tried Benadryl and I bet your child has a not uncommon paradoxical reaction to Benadryl! If it works, though, it's not really a bad idea for a long overseas flight. I'd test my child's reaction to Benadryl with a small dose beforehand, like on a day when 4 hours of hyper won't be such a big deal.
All this with your pediatrician's okay, of course -- there are various reasons not to give antihistamines to certain children. And under 12 months there's enough question about antihistamines and SIDS that I'd probably just tough it out, even with my pediatrician's approval. 35,000 feet is about the last place you want your baby to stop breathing (the first being four feet outside a NICU).