Sorry about being late on this, I had a gaseous expenditure of the cerebral cortex. It was a close week, but only one comic can win* -- Dueling Analogs and their topical strip about Link being voted "hottest male video game character" by Out magazine. 2nd place went to Concerned and 3rd is owned by Extra Life.
Honorable mention (as we forgot to include them -- not that it seemed to matter) goes to Penny Arcade. Thanks to everyone who voted, and be sure to let us know (via comments below, preferably) of any game-related webcomics you stumble upon this week!
* - unless in the unlikely situation that two winning comics win the exact same number of votes ... and that would be seriously cool.