Spring Cleaning, the system optimization, cleaning, and uninstaller utility from Smith Micro is now a Universal Binary. Completely rewritten from the ground up, version 9 introduces a wealth of new features and tools, such as a Task Scheduler, Permissions Fixer, a Housekeeping Scripts Runner, Spotlight Index Rebuilder, System Cache Cleaner, and others, in addition to a reworked interface. $49.99 for the package, or $19.99 for upgrades. Requires OS X 10.4. Although I can't vouch for this application, I will recommend OnyX for folks looking for something similar, and for free. I usually make sure to crack OnyX open every month or so for a bit of housekeeping of my own.