Strauss Zelnick believes the company can be profitable in a non-Grand Theft Auto year. Speaking with Venture Beat, Zelnick explains that while GTA may have been the main source of profitability before, Take-Two is a different company in the wake of titles like BioShock and Carnival Games. Reportedly, the company now has "30 million-plus selling titles, 15 of which are full owned."
Depending on the nature of the content in the first GTA IV DLC (expected later this year), the company might very well see some nice cash flow from the second episode next year. We also have no idea when to expect GTA: Chinatown Wars. From what we can see, GTA is going to be on the T2 fiscal calendar in one form or another for quite some time.