The latest Ask Cryptic focusing on Star Trek Online addresses a number of questions sci-fi fans have about where the IP is heading in the MMO space. Not surprisingly, many of the questions asked of Cryptic deal with how well they'll adhere to Star Trek canon.
The Cryptic Studios devs were asked about how they would handle the iconic story and characters of Star Trek, namely with voiceovers and cut scenes. The devs state that Star Trek Online avoids issues of tampering with Trekkie canon by setting the game in 2409, a good 30 years after Star Trek: Nemesis and Star Trek: Voyager. So while some of the locales familiar to Star Trek fans will be present in the game, players shouldn't expect to bump into any (or many) familiar faces.