Toilets seem to go hand-in-hand with Goichi Suda and No More Heroes. Around the time of the game's release, Suda mischievously compared making the game to defecating, and he's now revealed that he was inspired to make No More Heroes while perched on the porcelain throne. This in turn led to the title's quirky save mechanic, as seen above.
These are just two nuggets from a "Making of No More Heroes" piece at the Official Nintendo Magazine site. Suda also mentions how Johnny Knoxville influenced the character of Travis Touchdown, while artist Katsuyoshi Fukamachi and assistant director Toshihiro Fujikawa reflect on the myriad challenges they faced during No More Heroes' eight-month development cycle, including the chaotic final weeks, which both describe as a "total nightmare." It's definitely worth a read, partly because Suda is one of the industry's most entertaining and frank interviewees, but also because he's talking about one of the best Wii games of the last twelve months.