Comic-Con, Resident Evil 5 producer Masachika Kawata was asked if Albert Wesker would return in a future Resident Evil title, considering Resident Evil 5 leaves you believing he's gone. According to SIliconera, Kawata says Wesker's days in Resident Evil are over.
"Even if you want Albert Wesker to come back there is no chance of that happening," Kawata told the audience. Of course, Kawata forgets that Wesker will be seen in the upcoming Resident Evil: The Darkside Chronicles, which takes place in Raccoon City during Resident Evil 2's storyline. As for Wesker going the way of the Dodo, we'll believe that when we see it. Or don't see him, we should say.