We know from the lore of Guild Wars 2 that Ascalon will become what is literally a ghost town thanks to King Adelbern, his sword Magdaer, and his last-ditch effort to drive out the Charr in a cataclysm known as Foefire.
The effects of the event reach farther than anyone would have thought in the first Guild Wars 2 novel, now officially titled Ghosts of Ascalon. The ghosts of slain Ascalon soldiers are the only inhabitants of the area now, defending their home from invaders and generally making it a pretty unwelcoming place.
In Ghosts of Ascalon, Queen Jennah is attempting a treaty with the Charr, who are unwilling to deal until the Charr artifact the Claw of the Khan-Ur is retrieved from -- where else -- Ascalon City. A small band of adventurers sets out for Old Ascalon to retrieve the artifact from a dangerous land and an unwilling ghostly king. (Since Lion's Arch is gone, we assume they couldn't find anyone to run them.)
The book is scheduled for release this summer in North America and Europe. For now, check out the FAQ on the Guild Wars 2 site.