Pokémon Black and White.
Going by Andriasang's translation of the blog, players of the upcoming generation of Pokémon titles will only encounter all-new monsters until they clear the game. The developer hopes this will make the game a fresh experience for veterans and newcomers alike -- though Masuda admits that coming up with new monsters has been completely challenging. Well, yeah, we'd assume anything after number 300 would be tough to come up with. Here, we'll try: Stonedog! He's a dog! But he's made of stone.