Rise of Nightmares? While Sega hasn't revealed much, the game's page on the ESRB site describes a first-person "horror-adventure game in which players assume the role of an American tourist who must rescue his wife from a deranged scientist" holed up in a deserted mansion.
Deranged, indeed: "zombie-like creatures and disfigured monsters" stand in the American tourist's way, and he must employ "brass knuckles, knives, hatchets, and chainsaws" to get through them. Beyond physical harm, he'll have to wrestle with his own psyche, as "some female creatures are depicted in revealing outfits (e.g., 'pasties' that partially cover their breasts)." Stay focused, American tourist!
As a result of all these horrifying (and sexy) elements, Rise of Nightmares has been rated M for Mature. It's expected to launch sometime in 2011.