Mass Effect producer Casey Hudson revealed that his team at BioWare Edmonton has started work on "a whole new fictional universe." Other details weren't shared, except that Hudson said that he and BioWare's Senior Creative Director Preston Watamaniuk are going to be "building something new" together.
Hudson oversaw Mass Effect 3 as an executive producer, and he says he'll still serve that role on the next Mass Effect title. But that game is being developed at BioWare Montreal, so Hudson's team at BioWare Edmonton has moved on to something completely new. Hopefully we'll hear more about it soon.