Latest in Science

Image credit:

Scientists use nanoparticles to crush lingering fat cells

The treatment uses powerful drugs to beat obesity, while limiting side effects.
17 Shares
Share
Tweet
Share

Sponsored Links

If you think losing weight is simply diet plus exercise, the equation is not so simple. A recent study of Biggest Loser participants showed that even if you manage to drop pounds, your body will fight you for years afterward to gain them back. That's why scientists have put so much effort into studying obesity in an effort to help us fight our own genes. Researchers from MIT and Brigham and Women's Hospital think that our ubiquitous friends, nanoparticles, could deliver drugs to specific parts of the body, turning bad fat cells into good ones that burn fat.

The team started with a pair of drugs that are effective at transforming white "adipose" cells into brown ones that burn fat, rather than store it. While very effective at that chore, the drugs have adverse side effects that can limit their use. If targeted to specific parts of the body that contain fat, however, the negative consequences can be limited.

That's where the tech comes in: The drugs are stored in nanoparticles' hydrophobic cores using PLGA, a polymer commonly used in drug delivery systems and medical devices. The outer shell, meanwhile, is embedded with molecules that target proteins found uniquely in the blood vessels lining fatty adipose tissue. That turns the nanoparticles into guided missiles that seek out fat cells and release drugs to transform it.

When the system was tested in obese mice, the animals lost 10 percent of their body weight, improved cholesterol and triglyceride levels and showed a reduced risk for diabetes. One potential problem is the need to intravenously introduce the nanoparticles. "For it to be more broadly applicable for treatment of obesity, we have to come up with easier ways to administer [it]," says Omid Farokhzad from Brigham and Women's hospital. However, the team may be able to use nanoparticles that can be swallowed and absorbed through the digestive track.

The treatment has yet to be tested on humans, but could provide a new way to help obese patients, especially those at risk for diseases like diabetes. The Biggest Loser study shows that the metabolism of many folks drastically slows after successful weight loss, helping it return with a vengeance. If we can force our fat cells to work with us, rather than against us, we may be able to regain the advantage.

All products recommended by Engadget are selected by our editorial team, independent of our parent company. Some of our stories include affiliate links. If you buy something through one of these links, we may earn an affiliate commission.
Comment
Comments
Share
17 Shares
Share
Tweet
Share

Popular on Engadget

Nike puts an accessibility twist on its iconic Air Jordan 1

Nike puts an accessibility twist on its iconic Air Jordan 1

View
Alphabet’s Wing starts drone deliveries to US homes

Alphabet’s Wing starts drone deliveries to US homes

View
Boeing messages hint staff may have misled FAA about 737 Max

Boeing messages hint staff may have misled FAA about 737 Max

View
Judge refuses to block the release of ‘The Laundromat’ on Netflix

Judge refuses to block the release of ‘The Laundromat’ on Netflix

View
‘Plants vs. Zombies: Battle for Neighborville’ is available today

‘Plants vs. Zombies: Battle for Neighborville’ is available today

View

From around the web

Page 1Page 1ear iconeye iconFill 23text filevr