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Snail venom provides a new way to treat chronic pain
The Conus regius' venom is bad news for its prey, and it's been proven harmful to humans as well. For instance, a 2009 clinical case describes a diver who had trouble moving his arm for 12 hours after an attack. However, scientists from the University of Utah see hope in the ocean dweller's powerful venom. In fact, research suggests it could be used to develop a new treatment for chronic pain.
'Dishonored 2' gameplay teaser reveals new powers, casual time-travel
Finally, Bethesda gave us a real look at how Dishonored 2 will play. With a now grown-up Emily Kaldwin, players will get a chance to play as both her and the last game's protagonist, Corvo. Aside from gameplay changes, it will also offer different shades of the story depending on who you play with. But that's just the start. The game has really cranked up the detail of the world, aiming to better convey the backstory and fiction that also embodied the first game. To that end, it's got a new game engine as well: The Void engine. (It's a Dishonored thing.) And then there's the new power set.
ICYMI: The death-proof car, rat gambling addiction and more
#fivemin-widget-blogsmith-image-359509{display:none;} .cke_show_borders #fivemin-widget-blogsmith-image-359509, #postcontentcontainer #fivemin-widget-blogsmith-image-359509{width:570px;display:block;} try{document.getElementById("fivemin-widget-blogsmith-image-359509").style.display="none";}catch(e){}Today on In Case You Missed It: Volvo just pledged to build a 'deathproof' automobile by 2020 that will include adaptive cruise control and pedestrian detection. By 'deathproof,' it means unless you are crazy stupid (ie: Go flying off the Golden Gate Bridge in it), you won't be able to die in one of the company's cars.
Rat brains are basically wired up like miniature internets
Drawing on forty years of peer-reviewed research, a team of researchers from the University of Southern California have generated the world's first "wiring diagram" of a rat's central nervous system. And, as it turns out, their brain structures are uncannily similar to the internet's physical architecture. What's more, this could help us better understanding of our own neural organization. "The cerebral cortex is like a mini-Internet," USC professor and corresponding author of the study Larry Swanson said in a statement. "The Internet has countless local area networks that then connect with larger, regional networks and ultimately with the backbone of the Internet. The brain operates in a similar way."
Scientists can create and erase memories 'at will'
A person is the sum of their memories, so what happens when our personal histories can be deleted at will? That's the ethical dilemma facing researchers over at the University of California, San Diego, who have found that it's possible to delete and recover memories created in the minds of genetically engineered rats in the same way MIT scientists did with mice last year. In a slightly gruesome series of experiments, the rodents were given electric shocks while their neurons were bombarded by light pulses delivered by an optical fiber implanted into their brains. After a while, the shocks stopped, but whenever their brains were stimulated, the rats continued to feel fear, since they were drawing on memories.
Duke melds two rats' minds through the internet, Spock may not approve
Some would say the internet already lets us share every minute detail of our thoughts, much to our followers' dismay. Duke University isn't deterred by our behavior -- if anything, it just took oversharing literally by connecting two rats' minds in an experiment, first in a lab and ultimately online. Electrodes attached to the brain of a host "encoder" rat in Brazil processed the motor-oriented mental activity for a desired behavior, such as pressing a lever on cue, and converted it into a signal that was then received by a "decoder" rat as far away as Duke's US campus. The majority of the time, the decoder rat performed the same action as the encoder. Researchers also found that rewarding the encoder alongside the decoder created a virtuous loop, as treating the first rat for a job well done focused its attention and improved the signal strength. We're not sure that Vulcans would endorse this kind of mind meld, though: apart from immediately depriving the decoder rat of self-control, prolonged testing led to the same rodent developing additional sympathetic reactions to the encoder. There's also concerns that the test was too binary and didn't reflect the complexity of the whole brain. All the same, Duke's study is proof enough that we can export brainwaves in a meaningful way.
Fake jellyfish made from rat cells have a place in our hearts (video)
There's a whole sea of jellyfish out there ready to sting indiscriminately. So, why do we keep trying to make them? Scientists from Harvard and Caltech have a pretty good reason for creating fake jellies -- they hope to mend broken hearts by adapting their 'pumping' style of movement. Much like our own vital organ, the creatures are a mass of muscle adept at shifting fluid, meaning the research has several medical applications, such as bioengineered pacemakers for busted tickers. In creating the Medusoids, the team used a silicon scaffold coated in functional rat cardiac tissue, copying the muscle layout of a real jellyfish as best they could. When immersed in salt water and treated to bursts of current, the cells contract and cause the silicon sheet to move in a way eerily similar to the real thing. Next step for the team? An autonomous version that can move and potentially feed without their influence, of course. And, after seeing the little swimmers in action, we've certainly got palpitations. See what we mean after the break.
Researchers develop 'wireless optical brain router' to manipulate brain cells
Optogenetics might be a relatively unknown area of neuroscience, but it's one that, thanks to some new research, could soon find itself (and its rodental subjects) in the spotlight. For the uninitiated, it's the practice of manipulating animal cells using light (with a little help from gene therapy). Until now, optogenetic equipment has been large and unwieldy, making testing on subjects (read: rats) painstaking. Startup, Kendall Research, has changed all this, creating wireless prototypes that weigh just three grams (0.11 ounces). By eschewing bulky Lasers for LEDs and Laser diodes, the equipment is small enough that it can be attached to the rodents. At that point, their brain function can be manipulated with the touch of a button, and different parts can be stimulated without breeding mutant variants -- a controversial practice that doesn't even yield results in real time. The "router" is powered wirelessly by super capacitors below test area, and researchers can conduct experiments remotely, even automatically. Human applications for this are still some way off, but we're sure our future overlords will make good use of it.
The Daily Grind: What's your favorite in-game wildlife?
The general rule of MMOs is pretty simple to understand -- if it moves, either get a quest from it or kill it. Natural critters other than enemy soldiers exist mostly so that you can occasionally kill ten rats rather than killing ten beastmen. But from the chocobos of Final Fantasy XI to the elementally affected critters of RIFT, there are a plethora of different creatures that roam the land that you aren't necessarily meant to kill -- or at least those that serve a purpose in the world's ecology. In some games, such as the deep space setting of EVE Online, you're not going to find much in the way of wildlife. But in the games that do feature animals meandering about, which ones are your favorites? What local fauna catches your eye, either because it reminds you that the game takes place in a living world or just because it's so alien and bizarre? Every morning, the Massively bloggers probe the minds of their readers with deep, thought-provoking questions about that most serious of topics: massively online gaming. We crave your opinions, so grab your caffeinated beverage of choice and chime in on today's Daily Grind!
Scientists restore memory of drugged rats, hope to do the same with people
Is there anything we can't learn from drugged up rats? Researchers at Wake Forest University and the University of Southern California used a group of medicated rodents to demonstrate a method by which memory can be restored with the flick of a switch. The rats were outfitted with tiny, rat-sized electrodes and exposed to pharmacological substances, which caused them to forget the connection between pushing a lever and getting water. By turning the electronic switch on, the scientists restored the rats' memory of the task -- turning it off made them forget again. The next step in the process is testing the experiment out on primates and perhaps some day utilizing the research to benefit victims of strokes, Alzheimer's, or injury-induced memory loss.
EVE Evolved: Ratting, part 2: Flying safe!
Last week I discussed the basics of the "ratting" profession in EVE Online, from picking a good system to three popular ratting strategies. If you're planning to hunt NPCs in nullsec, of course, you'll need to get there first. Pilots who aren't in an alliance with secure access to nullsec will have to run the gauntlet from empire space to their chosen ratting system. The entry points into EVE's nullsec regions are often camped during peak hours and you can expect to run into roaming gangs. Things get a little easier once you're at your destination, but you can still expect to see the occasional pilot or gang passing through the system. Your ability to get into nullsec safely and your efficiency at ratting will be determined largely by the ship you're using and how it's set up. For someone who's never been to nullsec before, setting up a ship for the task and heading into the void can be a daunting task. In this article, I look at selecting the appropriate ship for ratting, some popular ship setups and important safety tips that will help keep your ship safe in hostile territory.
EVE Evolved: Ratting, part 1: Strategies
There are plenty of ways to make ISK in EVE Online, from exploration and mission-running to trading or any number of alternative professions. One of the oldest and most popular ways to make a reliable income in EVE is hunting the pirate NPCs that spawn in asteroid belts, an activity known as "ratting". Ratting is probably the best way to repair the low security status you'll be left with if you engage in piracy or suicide ganks. For those who live in nullsec, it's often the primary way to farm ISK for replacement ships to support PvP activities. Some players who don't have access to nullsec through their corporation or alliance even sneak characters in for the sole purpose of ratting. If done properly, it can make more ISK than level 4 missions and there's always that chance of finding rare faction and officer NPCs with valuable loot. In the first of this two-part guide, I look at where to find the best NPCs, how to find a good system for ratting and the three most popular ratting strategies.
One Shots: Rats
While most of the huge battles we hear about in low and null-sec space in EVE Online are player-versus-player, there are still skirmishes with NPCs in the game to be had. While they may not be the most epic battles, they aren't too bad when it comes to gathering up some ISK. Today's EVE Online One Shots from Andrew gives us a bit more information on it: "In an asteroid belt deep in the far reaches of null-sec space, a Heavy Assault Ship engages pirates belonging to the Angel Cartel. This kind of pirate hunting (called "ratting") is a major source of income for many residents of null-sec." From the large-scale battles to the everyday missions, we love to show off things players are doing -- but we need you to send your screenshots in! Just email them to us here at oneshots AT massively DOT com along with your name, the name of the game, and a quick description. Please make sure the image is at least 1024px across and has no visible UI. We'll post them out here and give you the credit. Couldn't be easier! %Gallery-85937%
Raytheon deploying Android-powered RATS on battlefields in Afghanistan and Pakistan
Android, Android everywhere. Android, Android in my hair. In my Nook and in my car in my netbook and in my... wait, Afghanistan? It seems defense contractor Raytheon, creators of the famous "pain ray", have launched a device called RATS: the Raytheon Android Tactical System. It allows soldiers to mark other soldiers and even UAVs as "buddies," then track their position in real time on a map, even picking up streaming video coming from above -- sort of like Latitude but putting a whole new spin on stalking. No word on how soldiers like their new devices so far, but once a Twitter app is added we're sure they won't shut up about it.
One Shots: Weekend ratting
var digg_url = 'http://digg.com/pc_games/EVE_Online_ratting_week_end_over_at_Massively_com'; As you may already know, we've been looking for a few good pilots to join our ranks here at Massively. The competition has been extremely tough, but we're almost at the end of the process. (Thank you for those who have been hanging in there!) To relax, some of us have been hanging out in EVE, enjoying many of the different aspects of game-play. Today's One Shot comes from one such (noob) adventure -- mine! This was taken while running a mission in Minmatar space, with a pile of rats bearing down on me, and a mining colony to save. Also: yum, lots of salvage.Do you have a great screenshot of Corp war, or of something equally exciting sitting in your screenshot folder gathering virtual dust? Why let it languish? Send those screenshots on to us at oneshots@massively.com along with whatever information you'd like to tell us about the scene in the picture. It could be here next. Until then, fly safe!%Gallery-9798%
WAR's must-have expansion races: Skaven
We're still months away from the release of Mythic's Warhammer Online, but already the robust fan community has spent a considerable amount of time debating which of the other Warhammer Fantasy races would be best suited to make the jump from the tabletop to the desktop. Whle the choices are quite plentiful, in my mind, there's no question which race is on the doorstep of gaming greatness; it's those lovably infectious rat-men, the Skaven. Today we take a look at the Skaven army, and lay out an illustrated blueprint for which of their many colorful units would fit into the MMO mold. %Gallery-21882%
Founding an old MMO on new ideas
Rock Paper Shotgun has posted an interesting thought experiment: what if you took two of the world's biggest MMOs, EVE Online and World of Warcraft, and combined their best features into some kind of super, Frankenstein, monster MMO? I'm actually really interested in this, because I've been playing WoW for a long time, and have only recently come around to playing EVE. So what would World of EVECraft look like?First of all, I completely agree with RPS-- the best new MMO feature in both games is EVE's skill system. Instead of killing X rats (rats both in the old standby MMO monsters, and in EVE's jargon for "Pirates") to level, you simply level. That's it. Choose a level, wait a certain amount of time (from a few minutes to a few days), and at the end of that time, even if you've logged out in between, you get that level. It is the perfect system for MMOs, because it really does make your character persistent-- they're leveling even when you're not.And as RPS points out, it does away with the basic idea of "levels" anyway-- no longer must you wait until your friend reaches your level to join you, and no longer does a foe simply become insurmountable based on a number. The skilling idea also helps in PvP as well-- no matter what your skills are or how good you are, you'll get better over time.So what can we take from World of Warcraft?
