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Breast cancer vaccine proves successful in tests on mice, moves on to human subjects
Here's a cause for optimism, albeit the cautious kind. Researchers at the Cleveland Clinic Lerner Research Institute have managed to isolate a human protein that plays part in the development of breast cancer, and have produced a vaccine against its creation that has delivered an impressive success rate in testing on mice. In a test group of genetically cancer-prone rodents, none of those injected with á-lactalbumin developed the potentially deadly disease. The progress of this drug trial to testing on humans has been met with reservation by cancer research groups, who remind us that we're years away from knowing if it will actually work on our species. Still, this is quite the little breakthrough and we hope all goes according to plan.
Panasonic banks on robot drug dispensers
Panasonic isn't the first company to turn to robots as a means for dispensing drugs, but it looks like it's set to become one of the bigger players in the still fledgling field, with it announcing today that it's developing a robot that it hopes will rake it about 30 billion yen (or $315 million) by 2016. Unfortunately, Panasonic isn't quite ready to actually show off the robot just yet, but it says it could be making the rounds at some Japanese hospitals by next March, and head into the United States and Europe sometime after that. It's also not ready to do much talking about specifics, with it only going so far as to say that it "does not look humanoid" but rather looks like "a cabinet with lots of small drawers" (no doubt somewhat like the Pyxis bot pictured above), and that it'll be able to store medical data for each patient and sort out prescriptions for up to 400 patients in about two hours. That cabinet won't come cheap though, with Panasonic estimating that it'll cost "several tens of millions of yen," or hundreds of thousands of dollars.[Via TG Daily, image courtesy Wikipedia / Jeremy Kemp]
Corkscrew nanopropellers may one day deliver drugs internally
Clearly, vaccinations are so three years ago. As the race continues to find the best, most mobile internal transportation device for delivering drugs to remote places within the body, Peer Fischer of The Rowland Institute at Harvard University has teamed with colleague Ambarish Ghosh to concoct the wild creation you see to the right. The glass-derived nanopropeller was designed to move in a corkscrew motion in order to plow through syrupy, viscous liquids within the human frame. The device itself is fantastically small, measuring just 200 to 300 nanometers across at the head and 1 to 2 micrometers long. Fischer points out that each of these can be controlled with a striking amount of precision via an external magnetic field, though we don't get the impression that they'll be on to FDA testing in the near future. Ah well, at least our gra, er, great-grandchildren will be all taken care of.
Light-activated lock could revolutionize drug delivery
The Gators may not be in the Final Four this year, but the brainiacs on campus are still toiling away, regardless. Researchers at the institution (that'd be the University of Florida) have just stumbled onto a remarkable discovery that could eventually "starve cancer tumors and prevent side effects from a wide range of drugs." The magic find? A "lock-like molecule" that clasps or unclasps based on exposure to light. Sure, we've seen our fair share of newfangled drug delivery tools, but none that have been this noninvasive or simple to activate. In tests, gurus found that they could use visible or ultraviolet light to open or close a clasp, letting blood flow or creating a clot; in theory, this could one day be used to "prevent the formation of tiny blood vessels that feed tumors." Everything about this sounds just fantastic on the surface, but seriously, can you imagine how dead we'd be if the robots ever got ahold of this?[Via Physorg, image courtesy of NanotechNow]
Outlaws of EVE Online: Masu'di Part 2
How do you handle the inevitable conflicts with territorial alliances who likely have greater numbers and firepower?Most of the areas of space we need access to are claimed, with various levels of effectiveness, by large and powerful territorial alliances. We can not begin to match them with manpower, so we have to take a more cracks between the pavement route.In EVE a little good will can go a long way. So we will always try an open upfront approach first, and try and build a mutually beneficial relationship. Cheap boosters, resource and information sharing are all things we try and bring to the table.However, whether this is accepted or not, very much depends on the organisation involved, and their modus operandi. Some alliances in EVE develop because their leaders have good business sense, focus and strategy, they know what they want for the alliance, and know what they can offer in return. Other organisations build up from a pure quest for power. For these organisations trading and business can take away from this. They prefer to try and do everything in-house as this is perceived as a sign of strength. "We moved a number of agents into their alliance, who could help facilitate the acquisition of the resources we needed. They provided intel, allowing us to conduct our own covert resource gathering, while causing internal disruption where possible." In the latter scenario we have to take a more covert approach, for example one recent alliance, former resident of Fountain, was an alliance called Brutally Clever Empire. We had already moved into the booster production constellation earlier, taking advantage of the chaos there when Band of Brothers pulled out. Not being perceived as a threat by anyone else we were generally low down on the target list and left alone to get on with what we like doing best. When Brutally Clever Empire arrived and claimed the region as their own, they wanted exclusive control of all the region's resources, and allow their in-house booster producers to build up a monopoly on the Exile booster type. However, the stronger boosters need resources from other regions too. It's something which we could easily provide and they tried to negotiate with us over this, however they refused to let us continue our access to our former operational areas – something which we found unacceptable.Without going into too much detail, we moved a number of agents into their alliance, who could help facilitate the acquisition of the resources we needed. They provided intel, allowing us to conduct our own covert resource gathering, while causing internal disruption where possible. We also we hired some mercenaries for a couple of months to harass Brutally Clever Empire, but luckily for us they had made enemies of most of their neighbours. With few friends and allies, and being yet another alliance that puts the wagon before the horse, they quickly collapsed.
Outlaws of EVE Online: Masu'di
Whether prowling low security space hunting for targets or fighting in massive fleet engagements, EVE Online's elite pilots -- called capsuleers -- stride like gods across galactic battle zones, as seen from the perspective of normal ship captains and crews. In this setting of New Eden, a capsuleer's neural interface with the ship allows his thoughts to regulate the vessel's performance; the will to survive coupled with fast reflexes equates to greater fortitude and speed in combat. Against conventional fleets, even a single capsuleer reigns supreme... but when faced with others of his caliber, or many of them, a capsuleer seeks every possible edge he can get. Some of EVE's pilots channel their resources into acquiring the most advanced technology, hoping to gain an advantage over their rivals. But others choose to invest in themselves through performance-enhancing drugs. These 'boosters' are outlawed in all secure regions of space, due to their powerful effects on a capsuleer's mind, and thus a magnified lethality of his ship. The demand for boosters is great, but so too are the costs. Boosters are contraband and risky to move in large quantities. Coupled with the arcane processes involved in creating these drugs, those in the know have formed cartels, whose booster production and smuggling operations form the underpinnings of New Eden's black market. The most pivotal figure in New Eden's booster trade is Masu'di, who heads the Hedonistic Imperative drug cartel through the corporate front of Es and Whizz. Their operations are largely hidden, as they dance around the power blocs of the largest capsuleer alliances, subtly influencing or corrupting those who hinder the narcotics trade. Their network operates between the cracks of New Eden's laws and systems, ensuring a steady flow of boosters into any corner of the galaxy where a capsuleer needs a fix.Massively recently spoke with Masu'di about the life of a drug kingpin in New Eden, and the inner workings of the black market in EVE.%Gallery-32364%
Carbon fiber Stiletto boat runs down baddies at 60 knots
If you had any urge whatsoever to try to your hand at drug trafficking over water while these "weird" economic times sort themselves out, uh, you may want to reevaluate your options. The ever-so-stealthy Stiletto has come to life after tracking down a remarkably quick drug-running boat near Florida; the bad guys were cruising at 42 knots, but that comic book-esque thing you're undoubtedly peering at above can reach speeds of up to 60 knots. The double-M-shaped hull enables it to navigate in extraordinarily shallow waters without trouble, and a plethora of sensors and radars give it all the power it needs to track down goons. Oddly enough, it's having a somewhat difficult time finding a government agency to truly call home, but if it continues to keep the coke out of our seas, we'd say it'll win over some hearts soon enough.[Thanks, Laz]
Bethesda: Fallout 3 to be 'identical' for Aussie, UK, US versions
Bethesda's VP of public relations, Pete Hines, has confirmed with Edge Online that the US, UK and Australian versions of Fallout 3 will be "identical" to one another. A reference to the real-world drug Morphine has been removed, explains Hines, to abide with each country's ratings and classification boards, replaced with "Med-X."While "material promoting or encouraging proscribed drug use" has been replaced with more fictional drug references, Pete Hines tells Joystiq that "nothing else" has changed, including the over-the-top violence we've been enjoying in the screenshots. Full statement from Hines after the break.%Gallery-3507%
CDEX's meth gun gets field tested
Last summer, CDEX's meth gun was marginally more than a drawing board creation made real, but now the drug scanner is actually being used in field tests before it hits the production line later this year. Reportedly, the device is being tested in Arizona, and it seems as though the trials are going quite smoothly. It's also noted that future iterations could actually posses the ability to "test other drugs as well, even explosives," but the current flavor should eventually cost somewhere between $500 and $600, which is still a great deal cheaper than we had previously heard.[Via The Raw Feed]
Brain Machine legally induces mind trip
We know, returning to work after an all-too-short long weekend leaves you just wanting more time off, but rather than skimming through those pictures you snapped and refusing to get back in the groove, why not force your brain to meditate and release those negative vibes? In an admittedly bizarre how-to guide, the folks over at MAKE have detailed Mitch Altman's Brain Machine, which reportedly enables you to slip into deep thought, sleep, or peaceful nirvana by syncing up your brain waves with pulsing lights and sounds. Odd as it may sound, the homegrown trip inducer purportedly utilizes an SLM (Sound and Light Machine) to "phase in new brain states by switching frequencies back and forth." Of course, we're still a bit hesitant to put our retinas at risk in order to legally experience hallucinations, but be sure to hit the read link for the step-by-step guide, and tap the via if you're interested in catching a video before subjecting yourself. [Warning: PDF read link][Via MAKE]
Handheld meth gun for drug detection
While the hefty yellow gun developed by CDEX Inc. may look like something from a 80s sci-fi film gone bad, it could eventually end up standard fare in a patrol car. Contrary to the title's implication the meth gun does not shoot uppers at what's in its crosshairs. The flamboyant device cracks down on crime by emitting small amounts of UV radiation onto a suspicious surface which causes most illegal substances to release a "spectral fingerprint" which the meth gun identifies. This investigative aid allows cops to detect and identify drug traces without even knowing (or suspecting) that chemical foul play was involved. The finalized version will scan for essentially any drug you can think of trying, but there's a fair amount of red tape and field testing that must be accomplished before this oversized neon pistol gets whipped out on a regular basis. Priced at around $10,000 this drug-buster isn't exactly cheap, but compared to desktop detectors that run upwards of 50 grand, we can envision quite a few precincts placing orders for what CDEX is dealing.
