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Gamers beat scientists to making a protein discovery
It's no great shock to see citizen scientists make discoveries that professionals miss, but making it through a video game? That's different. Gamers playing Foldit, a puzzle title that has teams trying to fold the best protein, have identified the shape of a protein before scientists (including two trained experts and 61 University of Michigan undergrads) could manage the feat. And it's not as if there were legions of contributors, either, as it took a relatively modest 469 players to help out.
Gamers pwn University of Washington scientists, solve decade-long simian AIDS protein conundrum (video)
No gamer's escaped the throes of adolescence without hearing the damning refrain, "Video games'll rot your brain." While scientific research into that claim has so far proved inconclusive, it turns out the preferred pastime of our digital era could potentially cure cancer, and even help prevent AIDS -- in monkeys. Utilizing crowdsourced results from the downloadable protein-manipulating "game" Foldit, scientists at the University of Washington were able to attain a successful model of the simian AIDS-causing Mason - Pfizer monkey virus retroviral protease. For over a decade, researchers have been arduously attempting to reconstruct the folded shape of M-PMV with the aid of the task-specific Rosetta software, but to no avail. Now, in what they're calling a possible first, gamers were able to do what scientific brains and algorithms could not, creating a sufficient model for molecular replacement -- all in just three weeks. Feel like dedicating your leisure hours to this worthwhile cause? Then be sure to hit up the source link below, and transform yourself from couch potato to couch crusader.
Gamers crack AIDS-related protein, science now obsolete
Doing something as simple as playing a computer game called Foldit, gamers have helped to unlock the secrets of a protein-cutting enzyme from a virus that resembles AIDS. Though that may not mean much to you, it's a breakthrough that could have real repercussions for those researching AIDS and cancer treatment. The specifics are ... complicated, but, in short, players of Foldit work together to fill in the parts of research that computers struggle with: namely, spatial reasoning. (Sort of like Folding@Home, only this requires your brainpower rather than unused PS3 horsepower.) This newest collaborative breakthrough is being published in research journal Nature: Structural & Molecular Biology. While our colleagues at Rock, Paper, Shotgun rush to bring you the heartwarming story, we're distracted by the far more pressing revelation of the study: Games have officially obviated the need for science. That's it, show's over. From now on, when we need an answer to the big questions, we'll make a video game about it. Leave your pocket protector with Valerie on the way out, Poindexter.
Online gamers solve microbiology puzzle, contribute to anti-HIV solutions
Hey guys, look! Gamers are good for something! After struggling for some time to successfully map the structure of M-PMV, "a protein involved in a virus that causes a form of simian AIDS," scientists decided to hand the task off into more capable hands. Unfortunately, the only hands they could find were those of online gamers. Always willing to rise to a challenge, however, the gamers didn't disappoint. Through the use of a program called Foldit, which takes the mapping of molecular structures and transforms them into a sort of puzzle game, gamers (particularly a group calling themselves the Foldit Contenders) were able to successfully map the protein. Scientists hope that the crowdsourced solution can be used to design new drugs, such as treatments for HIV. Way to prove our worth to society, folks. You've made us proud.
