recombineering
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Scientists take a big step toward creating custom organisms
Scientists dream of using custom organisms to fight illnesses or even build computers, but there's a problem: it's difficult to make the sweeping genetic changes that would give you exactly the lifeform you need. To that end, researchers have found a way to rewrite "large stretches" of genomes with synthetic DNA. The team modified salmonella bacteria by using step-by-step recombineering (that is, exchanging sequences between similar pieces of DNA) to patch in yeast-grown genes that were "amplified" to boost their quality. The result was salmonella with 1,557 replacements spread across 176 genes -- a huge change for a relatively simple organism.
