Choosing the right graphics card / chipset combo to give you the most bang for the buck is always tricky business, and even moreso when you're looking to get the most out of some brand new hardware like AMD's Radeon
HD 4000 series cards. Thankfully, the folks at Legion Hardware have now stepped in to help out a bit, although, as is often the case, it's not entirely a clear cut choice. If it's a bargain you're looking for though (relatively speaking), it seems like pairing an ASUS P45 motherboard with a couple of Radeon HD 4850 graphics cards (for a total of about $550) will give you enough performance to impress all but the most demanding gamer. If you want to push those benchmarks as far as possible, however, you'll have to go up to an ASUS X48 board, although even the folks at Legion Hardware question whether the mere 5% performance gain is worth the extra cost. If you want to make your own decision though, you can hit up the link below and dig through the numbers yourself.
[Via PC Perspective