Rebuild your entire desk out of 8020 (http://www.8020.net/) (no really) and make it modular to start with. Then, attach some conduit to help guide permanent cabling, (with wire ties as well) and finally put yourself a usb farm (hub) flush with the desktop, so you don't need 100 cables going back to your desktop.
The Cobra Tag may help you win that losing battle, acting as a Bluetooth device that attaches to your key ring and connects to your phone, it gives you the opportunity to find the missing item if it's less than 30 feet away.
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Rebuild your entire desk out of 8020 (http://www.8020.net/) (no really) and make it modular to start with. Then, attach some conduit to help guide permanent cabling, (with wire ties as well) and finally put yourself a usb farm (hub) flush with the desktop, so you don't need 100 cables going back to your desktop.