Facebook CEO Mark Zuckerberg. Why? Well, Time says it's because his creation has "wired together a twelfth of humanity," but we think a certain highly dramatized blockbuster movie might have something to do with it. Really, it's not luck the Zuck did that much in 2010, except tell some uncomfortable stories when launching Seamless Messaging. Runners up include Afghanistan President Hamid Karzai, who had another rough year, and Wikileaks' Julian Assange, who is currently having a rather rough December after shaking up international relations all year long.