What Can I Delete from My Brand-spanking New Mac?

Someone recently commented the following on a very old post: "I don't know if anyone is still reading this thread, but if so...I just bought my first mac. its a mini. I went with the 40gb drive because I have external drive with 200g for video editing. I like to keep that drive devoted to video files. unfortunately it seems apple has given me 20g of stuff on my drive already. after my 9.5g music collection I'm left with 10g to work with. my question is What Can I Delete from My Brand-spanking New Mac?"

My brief advice: Basically, you can remove anything inside the Applications folder [UPDATE: Anything that is non-System Software that is; don't erase QuickTime or a good deal of the bits in the Utilities folder; thanks to the commenter who pointed out my oversight] with little fear of bad mojo coming your way. You can also remove any extra files the System may have stashed in your Documents, Music, Movies, or Pictures folders. Everything else is a bit risky unless you are very careful. If you never use Classic, you can uninstall it and everything in the corresponding Classic Apps folder. You could also wipe the drive clean then reinstall the OS, choosing custom and avoid any foreign language support modules or printer drivers that you won't need. You could also do what I do and keep all of your music on your iPod while convincing iTunes that those files are all local to your Library. If you choose this method, make sure you keep external backups of all your tunes.

What does everyone else think? Is there any other way to free up as much space as possible on your internal hard drive?