Here's some fantastic news: ScummVM can now be run on the Wii! Rodolfo Portillo just released a Gamecube version of the program, which allows classic LucasArts adventure games (and others!) to be run on systems other than the old PC's they were designed for.
You still have to have the original files, and you have to have a Gamecube SD adapter, but you guys all have your own copies of Sam & Max Hit the Road, right? Right? One other small issue: this isn't a Wii-specific port, so Wiimote pointing is out.