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Man, this Destroy All Humans: Big Willy Unleashed lays on the topical humor, and thick. Apparently this time Crypto is charged with stopping a Patty Hearst parody from inciting public outrage against the aliens' Big Willy's fast-food franchise, which, of course, was created to serve man. Apparently fast food is bad for you! On top of all of the cultural references is a layer of self-referential humor which is less than subtle: Crypto's boss Pox refers to his "previous video game adventures," and the two riff on the 'blink, then disappear' death style common in games.

If there's anything of which all should be destroyed, it's the Jack Nicholson impression used for Crypto's voice.