Simon Jeffrey, known around some parts as the President of Sega, is either very smart or ... not. It's a fairly simple story here -- he casually mentioned Resident Evil 5 in an interview about MadWorld, saying "when that [Resident Evil 5] happens on the Wii, it'll help," referring to attracting more hardcore gamers to the platform.
Later, he referred to the comment as a "slip of the tongue," but that doesn't mean it's not true. If it wasn't true, he would say "mistake". We're not going to hoist the confirmed flag or anything (as some have been awfully quick to do so), but a guy so high up in the industry couldn't possibly pull this rumor out of thin air on the spot, right? We'll keep you updated, so any RE5 hopefuls should stay tuned!