last time we heard from ioSafe they were taking 2.5-inch HDDs, wrapping them in armor, then stuffing them into 3.5-inch enclosures -- adding fire and water protection in a standard form factor. Now they've given up on the internal route and have gone for something a little larger and more durable, fitting Western Digital or Seagate disks into hardened external USB 2.0 cases capable of being submersed in ten feet of water for three days or surviving a raging inferno for 30 minutes. $199 gets you a 500GB model, but, since you'd probably have a hard time upgrading the drive in there without a jackhammer, we'd recommend going straight for the $349 1.5TB model -- early adopters get a tidy $50 off!
Update: Jason commented to let us know they also use Seagate drives.
ioSafe announces Solo, the external, submersible, fire-proof HDD enclosure
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