World of Darkness canned, the closest fans can get to experiencing the source material in video game form comes from Activision's 2003 Vampire: The Masquerade - Bloodlines. Unfortunately, the game was released in a half-finished state and suffers from multiple glitches, balance issues, and general weirdness, not to mention graphics that have aged very poorly. Fortunately, the fan community rallied and set to work on an unofficial remake requiring the original. Double-unfortunately, CCP Games sent that fan remake a cease-and-desist.
Although Activision technically owns the rights to the game, the IP remains in the hands of CCP due to its acquisition of White Wolf several years prior. The fans responsible for the remake are attempting to negotiate a way to keep development going, as the remake would have been unplayable without the original game. It's bad news for fans of the flawed but brilliant title and really anyone who would like to play a game based off the franchise any time within the next decade.