If you aren't using Carbon Copy Cloner, then you're missing out. This gem of an app is the easiest way to clone one Mac drive to another (you can even clone bootable volumes, so you can backup your main Mac drive to a stand by drive and boot right off of it). In addition to the clone ability, Carbon Copy Cloner makes backing up a breeze, and it is easier with Carbon Copy Cloner 3.
The new version of CCC brings with it better data synchronization, block level copying, and some nice UI enhancements.
Carbon Copy Cloner is donation-ware, so it is fully functional but if you use it you should really considering donating some cash to help with the development of the app.