In Hana Yori Dango the main character is Tsukushi, a working-class girl attending a school full of rich kids. The most elite of the elite is a group known as the "Flower" Four (F4), who make it a hobby to harass other students. In the manga (and show), Tsukushi stands up for herself against the group, which causes the F4 leader to fall for her.
In the DS game based on the franchise, called Hana Yori Dango -Koi Seyo Otome!-, you take control of a new girl that essentially fulfills the same role as Tsukushi. Whether or not she finds romance with one of the F4 crew depends on how you play the virtual dating game, which includes stylus-controlled hand-holding and other kinds of mini games.
This title comes out in the Far East on July 10th, so all you gals (and guys!) who don't mind navigating through Japanese text to land yourselves a virtual man, mark that date.