They start out by talking about the changes with 10 and 25 man raiding, and Kaplan says plainly that the Burning Crusade endgame was just too plain hard: "We just had: 'OK, welcome to level 70, here's a brick wall. Maybe you can climb it.'" There will still be a hardcore endgame in Wrath, but it'll be later on, near the very end of the raiding ladder. They also describe Wrath as a "coming home" moment -- after an "exploratory" period in Outland, Wrath will be a return to Warcraft's tradition and lore. And perhaps most surprising, Brack actually lends a lot of credence to a question about a graphical overhaul "from the ground up." He says that by the next expansion they'll "probably" have to look at updating the graphics system completely.
And finally, Blizzard believes that yes, even though it doesn't seem like it now, eventually there'll be something bigger than World of Warcraft. Brack's last word is an interesting look at the future: "Something will come along and WoW will be like EverQuest: a great game I played back in the day."