Mice run through Quake, Princeton neuroscientists scan their brains for traces of evil (video)
Want to know just how prevalent technology has become in our lives? Now even lab mice get Quake-derived virtual reality playgrounds to navigate instead of their old school wooden mazes. In all honesty, this appears a significant and praiseworthy advancement, as the Princeton team have succeeded in mapping brain activity right down to the cellular level, with real-time tracking of single neurons now possible. The Orwellian-looking setup above is necessary in order to keep the mouse's head immobile, and thus capable of being studied, while the animal moves around and its brain performs motion-related tasks. Go past the break to see a schematic of the scanner and a quite unmissable video of it in action.
[Via Switched]
[Via Switched]




















oh my garage
Who designed this map? It sucks!
Also, the url is...ehm, just not right.
This video sucks without NiN music.
Can you imagine hooking a human up to that? Maybe that will be the next saw movie
God, no, cause then we'd have to sit through a crappy 3D animated Jigsaw. Now, THAT is scary.
Didn't we already see that in The Lawnmower Man?
or maybe an augmented reality alternative gameplay experience.
Am I the only one laughing at a mouse on a giant trackball?
I thought it looked like a giant Space Orb. brings back memories. :)
Pretty awesome to watch isn't it! I'm damn impressed with the little guy running around. (Also saw the irony in a mouse controlling an optical mouse.)
I'm laughing at a mouse with a helmet strapped on (since they held its head still), running on a giant trackball
That would be a mouse using a mouse?
Yo dawg...
not anymore, I'm laughing now, too!
no lol yo'r not the only one...
What is he doing to bozzo the clowns bald head? lol
I like at :37 where the mouse thinks it is going to hit the wall and skids to a stop. Must be a pretty immersive experience.
good point. otherwise it looks like the mouse is just running in circles becausre it's head is in a vice, as noted by @ryan below.
Wow since when did mice started having better gaming experiences than humans?
I record single cells also, albeit in other animals.
The advance here is not single-cell recording, but being able to simulate movement without actually moving and killing the cell you are trying to record. Cell recording itself has been done for decades, with the earliest I am familiar with being in the 1970's, when it took off. The technique has largely stayed the same, though modern storage and processing speed allow us to analyze the data in much more sophisticated ways. In the early days, they literally just printed out traces and tried to come to a conclusion about the general behavior.
They should make the mice play Silent Hill.
not much of a maze is it...
i'm unconvinced the mouse isn't just running terrified in circles cause its head is in a vice
Pop quiz, if you could play an FPS in full on virtual reality but your head has to be in a vice the whole time... Would you do it?
> but your head has to be in a vice the whole time... Would you do it?
What kind of a stupid question is that? Of course I would...
I would like to see what the mouse would do if they dropped the monsters back into the maze... or maybe even a cat. Then they could map the part of his brain that goes "oh s&&t".
I'm pretty sure the reason that its running in a circle is because each time it goes under the striped cylinder, it gets a squirt of water as its "treat." I heard David Tank describe this experiment, and if I remember correctly, it is the mouse getting the water as a reward. On the diagram for the setup, you can see the water tube, and I think that's what its for.
Pretty crappy reward if you ask me though.
I was wondering about that myself; where exactly is the maze? it seems to just be a square room with four cylinders hanging from the ceiling...
The real test: throw in a virtual running wheel.
The real-er test: spawn a Thunderbolt and some zombies...
i didn't RTFA, but i hope it is a vice and not screws!
yeah, it's more like a horror movie than an experiment. that mouse is seriously wondering if it's in hell.
can i please have their grant money? i will do something useful with it.
Yo dawg, I heard you like mice. So we put a mouse in yo mouse so you can mice while you mice.
Nice meme usage!
My favorite part - the notation "optical mouse". To distinguish from the animal mouse.
Damn, was waiting for it to get some frags / get fragged
But can the mouse play Crysis?
Damnit, you beat me to it.
Meh... I'll be impressed when the mouse figures out Descent.
I think this is the first time this meme has gotten a laugh out of me :)
maybe we can join his clan?
I want to see the mouse play Portal. This would impress me immensely.
I must be dumb I guess cause all I see is a mouse running to the right the whole time
Looks like a mouse NASCAR, except it's all right turns. MOUSECAR.
Put the monsters back in and give the mouse a nail gun and quad damage...
+1. I want to see that.
No GlQuake?
Evil is in the scientists' brain that torture animals daily.
Animals are not ours to experiment on.
yes they are
No worries my trolling friend, we'll just gather up all the hippies and use them instead. Fuck it, what's one evil over another right? Right?
Chances are that given a direct and immediate choice to sacrifice an animal's life in favor of your own you'll do it: Just like that London vegan that chose to have a pig's heart valve installed. The rest of us realize that the animals aren't used for shits and grins, but to prevent unproven experimentation on humans.
The Lab/Scientist/University probably paid a solid 50 cents for the rat, therefore, it is in fact the property of said purchaser.
http://en.wikipedia.org/wiki/Speciesism
Tiago, shut up. Please.
If you really believe the crap you are spewing then you should be in a cave eating plants and not using or relying on any of humanity's advancements. You're a hypocrite just for being here moaning today.