The comic illustrates players' ability in the breeding game to mash two cats together in order to create a new kitten, care for them as well as enter them into battles and pageant-style contests. Team Meat previously referred to Mew-Genics as a "cat lady sim" that blends elements of "The Sims and Pokemon with a sprinkling of Animal Crossing and a dash of Tamagotchi."
McMillen likened Mew-Genics to an unreleased Nintendo game called Cabbage that was in development by Earthbound creator Shigesato Itoi and Mario creator Shigeru Miyamoto for the canceled Nintendo 64DD system. Cabbage was a multiplayer breeding game that was expected to allow players to take their creature on the go with their Game Boy systems. Mew-Genics is in development for Steam, iOS and Android, and will launch in 2014.