Padilha recently uploaded images to his DeviantArt account which depict League of Legends characters squaring off in traditional Street Fighter-esque mano a mano fisticuffs. While Padilha clearly owes much of his personal style to anime and manga influences - somehow even moreso than Capcom's stable of Japanese artists - he does an excellent job of translating champions from one medium to another.
Even more impressive are the backgrounds Padilha has designed, which depict small scenes drawn from League of Legends' various battlegrounds with a slightly muted color palette. This tone seems more apropos for the source material, even as it contrasts with the more cartoonish style Padilha lends his characters.
You can find the entirety of Padilha's efforts by visiting his DeviantArt page, along with a much higher resolution version of the image above.