In the sequel, the roles have reversed and now the Mini Marios must save the day. With several obstacles in their path, players must guide the Mini Marios using the stylus and touch-screen. More interesting, however, is the ability for players to create custom maps and send them to other users via Nintendo's Wi-Fi Connect service. Overall, the game has received favorable scores:
- Gamespot - 82%: "Mario vs. Donkey Kong 2 may not play quite the same way the original game did, but the new take on the formula is a fun and refreshing one. The touch-screen controls are easy to get a handle on, and with more than 80 different stages to play through, as well as the construction mode, you'll find yourself with plenty to do. It's simply a great time for Mario fans and puzzle fans alike."
- IGN - 70%: "The original Mario vs. Donkey Kong is a far better puzzle game than March of the Minis is, but that doesn't make this game a bad one. It is a clever Lemmings-inspired, touch screen design with a great focus on user-submitted content to keep the game going on and on. Its similarities to the first game are only in looks; the concept goes in a refreshingly different -- but just not as successful, addictive or challenging -- direction for Nintendo DS gamers."
- Gamepro - 85%: "As a sequel, Mario vs. Donkey Kong: March of the Minis surpasses the original by leaps and bounds backed by the capabilities of the Nintendo DS, however the new control scheme does take some getting used to."