GameBump spotted this Shadow of the Colossus appearance in a trailer for the upcoming Adam Sandler drama Reign Over Me, which also stars Don Cheadle. So does Fumito Ueda's wonderful PlayStation 2 epic play a significant role in the plot? Probably not. Still, that a major Hollywood production would opt to use a game that is not easily recognizable to a mainstream audience is significant enough.
Unfortunately, the cameo, as framed by the trailer, is pinned to the old stereotype that when guys get to playing video games they neglect more important obligations (okay, sometimes we do), but the usage of Shadow of the Colossus also ties into an overarching maturation of the games industry; one that is forcing mainstream perception to shifts its view and embrace the critical impact games have on many adult lives. Nice work, Mr. Binder.