I'm pretty sure that the SDK license agreement explicitly forbids super-villainous activities, but no silly piece of paper (or PDF) is going to stop Dr. Horrible. The would-be world ruler who can't catch a break (either from his laundromat crush or from arch-nemesis Captain Hammer) is seen using his iPhone to remote-control a van in the debut episode of Dr. Horrible's Sing-Along Blog, the three-part Internet mini musical from Buffy & Firefly creator Joss Whedon. Clearly, the grand cinematic iPhone tradition of Journeyman lives on.
Close examination of Doc H's UI indicates that he's actually using Mobile Safari to steer his van, so perhaps that's how he's remaining on the right side of the EULA -- although that radioactive icon on the left is quite ominous. If you want to see it in action for yourself, check the gallery below, watch Act I for free on drhorrible.com (which is getting Captain Hammered itself right now, so you may have to wait a while) or pick up the episode on iTunes.