Jun Takeuchi is ready to hit the reset button for the next game in the series. Speaking with 1UP, Takeuchi believes that a reboot is possible for Resident Evil 6. No further details were given, so it's unclear whether he means RE3 to RE4 type change, or something bigger.
In our interview with Takeuchi, we did ask what the plans are for RE6. The producer told us that Capcom is simply in the "thinking about it stage" of development. However, he does believe that if too much time goes by between this installment and the next, that people lose expectation. Probably not a good idea to wait too long between franchise installments, though, as other games can fill people's heads with new expectations.