Update: Microsoft has assured Joystiq that Twitter is not going to be integrated into Fable III. According to Microsoft, "what Peter meant was he was inspired by the 'followers' mechanic on Twitter, and its influence can be seen specifically in the 'Follower' feature [of Fable III]."
Original: "Fable III Twitter integration revealed"
During his panel at GDC 2010, Lionhead's Peter Molyneux revealed that Fable III will include some form of Twitter support. Molyneux discussed the game's experience system, noting that the most important thing in Fable III is to acquire followers. We've heard that before, but then Molyneux said he was going to give the audience a "clue" about a new feature, but that he wasn't allowed to say more. Said Molyneux, "I Twitter now and, you know, I've got followers on Twitter. That's an interesting mechanic, and we integrate that into the Fable experience."
True to his word, Molyneux didn't drop any further hints, but considering that followers are akin to experience points in Fable III, we're assuming @conanobrien will soon rule us all.