Origin, you'll have the option to do so. An EA representative confirmed with Joystiq that the title would be available for purchase on other digital distribution platforms, though a list of stores has yet to be finalized. SimCity is arriving sometime in 2013.
Lead designer Stone Librande confirmed that SimCity would be an internet-dependent experience. Players will need to be online on Origin while playing, even if that wasn't the point of purchase. The always-on connection becomes necessary with the game's emphasis on multiplayer and regional impact, and the use of a global economy that all players can influence.