Binary Domain didn't have a very good March. According to data Joystiq received from the NPD, Sega's sci-fi shooter only sold 20,000 copies during the month. Compare that to the 1.3 million physical copies sold of the other big sci-fi game of March, Mass Effect 3.
Of course, Binary Domain had a lot going against it. For one, it's called Binary Domain. There was little-to-no marketing, whereas Mass Effect 3 ads were everywhere and everything you bought came with DLC. In the sci-fi wars of March, 2012, Mass Effect 3 emerged victorious.
As the last big boxed product from Sega, this disappointing performance likely contributed to Sega's decision to drastically alter its publishing strategy and issue substantial layoffs worldwide at the end of March.