Part of my blogging workflow uses Skitch for screenshots. As a result, I wind up with images all over my desktop at the end of the day like, well, a messy desktop after a busy day. If you find yourself with files constantly cluttering your desktop as well, check out Desktop Tidy on the Mac App Store. It'll hide those files clogging up your workspace at intervals you set, from every few seconds to every few days. But wait, there's more!
Desktop Tidy includes a ton of customization features. Sure, it stashes your files away in your Library folder where Spotlight won't index them (and Finder likes to hide the Library folder by default these days), but that's part of the beauty of the app. Using the menu bar, you'll easily see what files were sent over, make them come back, or search and organize them on the fly.
Here's a neat trick: Ctrl-clicking an item in the menu will restore it to your desktop.
There are filters for filetypes which will allow you to easily spot the files you may typically save to the desktop. In my case these are image files, and Desktop Tidy comes already configured to show a filter of images, easily accessed from the menu bar. In a way, this is easier than mucking about on the desktop itself.
Yes there are other tools and ways to do this, but I think Tidy gives the user a ton of options and ease of use for a decent price (currently US$4.99).
Check out Desktop Tidy if you just can't stand having all those files littering your desktop, no matter how tiny you make them.