Defiance has a fever, and the only prescription is... um... well, that's actually a good question. Nobody is sure. The entire focus of the new in-game event is trying to figure out how this fever can be treated. Presumably attempts involving bottles of Sprite and bed rest were inconclusive, and now you're going to have to go shoot some things to try to find the cure.
This mini-event offers characters a new Pursuit, which can be cleared to improve your EGO rating, with players seeking out three data recorders to help assemble a cure to the sickness sweeping the Bay area. Triage centers have been established in both Top Notch and Shandu's Consulate. Avid players should get in on this event while it lasts -- there have been no dates given, but it seems this disease will either burn out or get worse fairly quickly.
[Update: This event starts on June 3 and the corresponding TV episode runs on June 17.]